Cordarone Tablets can cause your skin to be more sensitive to the sun or to turn bluish-gray color. Cardiac glycosides eg, digoxin Digoxin levels are increased and may result in toxicity. Use effective birth control, and tell your doctor online-rezept amiodarone if you become pregnant during treatment. In addition to the interactions noted above, chronic weeks oral Cordarone administration imp airs metabolism of phenytoin, dextromethorphan, and methotrexate. Initial dose PO Loading doses of 800 to 1600 mg day are required for to weeks occasionally longer until initial therapeutic response occurs. If diagnosis of Amiodarone-induced hypersensitivity pneumonitis is made, Amiodarone should be discontinued, and treatment with steroids should be instituted. Because of the serious nature of the arrhythmia and the lack of predictable time course of effect, loading should be performed in hospital setting.